Recent crystal structures of the 50S subunit of the Escherichia coli and Thermus thermophilus ribosome in complex with CAM revealed that CAM binds to the A-site of the 50S subunit and occupies the binding site for the amino-acyl moiety of the A-site
99 The major chloramphenicol resistance mechanism is the acquisition of a chloramphenicol acetyltransferase (CAT)
inhibits protein synthesis
Study with Quizlet and memorize flashcards containing terms like Of the following list, which antibiotics affect protein synthesis? Select one: a
Both tetracycline and chloramphenicol are correct
These drugs may cause gastrointestinal irritation, phototoxic dermatitis, diarrhea, vestibular damage, and hepatotoxicity in pregnant women
It is highly soluble in ethanol and stable in aqueous solutions
The antibiotic does not exert its effect on protein Chloramphenicol is a bacteriostatic protein synthesis inhibitor
Here, we present a new 10mer chloramphenicol peptide, which exerts a dual inhibition effect on the ribosome function affecting two distinct areas of the ribosome, namely the peptidyl transferase center and the polypeptide exit tunnel
The R and R’ designations refer to the rest of each amino acid AG's bind to the 30S ribosomal subunit, whereas chloramphenicol, macrolides, lincosamides, and streptogramin B bind to the 50S ribosomal subunit to suppress protein synthesis Alteration in PBP: Modification of the PBP is a favored mechanism of resistance to Gram-positive bacteria, whereas production of β-lactamases is a mechanism for the The deletion of nine residues from the C-terminus of the bacterial chloramphenicol acetyltransferase (CAT) results in deposition of the mutant protein in cytoplasmic inclusion bodies and loss of chloramphenicol resistance in Escherichia coli