Purpose: Due to the complex pharmacokinetic profiles of phenytoin (PHT) and fosphenytoin (FOS), achieving sustained, targeted serum PHT levels in the first day of
It is in the anticonvulsants class of drugs
Synod Hospital is a multispeciality secondary hospital located in Durtlang, on the outskirts of Aizawl, the capital of the state of Mizoram
For patients receiving extended-release phenytoin sodium capsules who are stabilized on a dosage of 100 mg 3 times daily, may consider once-daily dosing with 300 mg as
• The time required for a phenytoin concentration to decline from an initial concentration (C i ) to a lower concentration (C) may be estimated by the following equation, which assumes that no absorp-tion occurs in the time between C i and C: i mi max C (K ) ln (C C) C t V V cortical areas
Includes dosages for Seizures, Status Epilepticus and Seizure Prophylaxis During or Following Neurosurgery; plus renal, liver and dialysis adjustments
In both patients, there is a linear relationship between the dose and the plasma concentration at
what does the time to steady state depend on for phenytoin and fosphenytoin? Phenytoin or fosphenytoin, with: Brivaracetam; Decreased brivaracetam effect (increased metabolism by CYP2C19) The magnitude of effect due to a drug interaction can vary widely based upon phenytoin serum level, and a new steady-state phenytoin level may not occur until 2 to 3 weeks following an alteration of therapy
Voriconazole
7 L/kg (15 Clinical Significance
Stop using fosphenytoin and get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling)
Fosphenytoin solutions are freely soluble in water, do not contain propylene glycol, and have an adjusted pH of 6–9
Pharmacokinetic parameters of phenytoin, such as total clearance and central and peripheral volume of distribution were influenced by body weight
The rate of intravenous phenytoin administration should not exceed 50 mg/minute in adults and 1 to 3 mg/kg/minute (or 50 mg/minute, whichever is slower) in pediatric patients because of the risk of severe hypotension and cardiac arrhythmias
1
2 for patients with renal failure (see
* Component test codes cannot be used to order tests
The volume of distribution of fosphenytoin increases with fosphenytoin dose and rate, and ranges from 4