Jul 4, 2023 · Administration
They come in three strengths: 25 milligrams (mg) 50 mg; 100 mg; Brand-name versions
Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassiumlevels in the
The classification of spironolactone as a "potassium-sparing diuretic" has been described as obsolete
Aldactone (spironolactone) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney
Spironolactone is a
Spironolactone is of value in the treatment of oedema
Spironolactone is a medicine that belongs to the class of medicines known as potassium-sparing diuretics (water tablets)
Gastrointestinal disorders such as abdominal pain, diarrhea, constipation, and vomiting
However, some diuretics can also cause the body to eliminate more potassium in the urine
Spironolactone oral dosing is as an oral tablet in 25 mg, 50 mg, or 100 mg doses and the maximum daily is dependent on the indication as follows: 1) 50 mg daily for HFrEF 2) 100 mg daily for
This risk is increased when used in association with potassium supplements and salt substitutes, as previously noted
Available forms : Tablets—25, 50, 100 mg ADULTS
Spironolactone acts primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule
Aldosterone antagonist diuretic, potassium-sparing diuretic: Used for: Fluid retention Heart failure Primary hyperaldosteronism: Also called: Aldactone®; Because spironolactone is a potassium-conserving diuretic, you should try to avoid things with a high potassium content, such as 'salt substitutes' or low-sodium salt
Hyperkalemia • With fixed-dosage combinations of potassium-sparing and thiazide diuretics, the thiazide-induced hypokalemia and metabolic alkalosis are ameliorated
Diuretics cause water loss and are used to treat a variety of conditions, including high blood pressure, heart failure, and diseases of the kidneys and liver
Spironolactone (brand names: Aldactone and CaroSpir) is a potassium-sparing diuretic (“water pill”) approved by the U
Physical exam shows 2+ pitting edema in the knees bilaterally and faint crackles on auscultation of the
, spironolactone [Aldactone]) can correct hypokalemia and give additional help in Spironolactone was recently reported to exert anti-cancer effects by suppressing DNA damage repair
These include eplerenone, amiloride, spironolactone, and triamterene
[2] It is FDA indicated to be used adjunctively with thiazides [3] (or other kaliuretic agents) for the treatment of chronic heart failure or uncomplicated essential Diuretics, also called water pills, are medications that act on the kidneys to increase diuresis, or the production of urine, to help excrete more water from the body
There are three main types of diuretics: thiazides, loop diuretics and potassium‐sparing diuretics
Spironolactone is a steroid which competitively antagonises aldosterone in the distal renal tubule; triamterene and amiloride directly affect electrolyte transport in the distal tubule without antagonising