Abstract The evidence for the efficacy of anticonvulsant drugs in the control of seizures during alcohol withdrawal is examined
A single alcohol withdrawal seizure: Seizures occur in one third of patients withdrawing from alcohol, and may even develop long-term AEDs are indicated, as
The authors suggest that the well-documented risks of intravenous phenytoin, such as cardiac arrhythmias, hypotension, and injection-site reactions
Phenytoin Phenytoin kinetics during long-term alcohol use and withdrawal were studied in 11 male alcoholics with a history of withdrawal seizures and no evidence of chronic
Alcohol withdrawal also lowers the seizure threshold, so don't suddenly stop drinking if you have been drinking excessively
During the first few days of taking phenytoin, it's best to stop drinking alcohol until you see how the medicine affects you
Alcohol withdrawal manifests as a continuum, ranging from tremor to seizures, hallucinations, and life-threatening
It is also used to prevent and treat seizures that occur during brain surgery
Hepatic enzyme induction (carbamazepine, phenytoin, phenobarbital) causes unpredictable pharmacokinetics (carbamazepine
Once the patient is stabilized and immediate life threats are identified, the
Alcohol-related seizures
Moreover, based on animal studies, phenytoin may be harmful when used to treat seizures induced by lidocaine, theophylline or tricyclic antidepressants 41, 63, 64
Phenytoin is cleared by CYP 2C9 and 2C19, leading to drug-drug interactions
Those patients who developed seizures during detoxification admitted previous abuse of benzodiazepines or erratic use of phenytoin
This medicine is an anticonvulsant that works in the brain tissue to stop
Phenytoin (Dilantin) 20mg/kg divided in maximum doses of 400mg every 2 hours:
Diazepam
Alcohol acts on the brain through various mechanisms that influence seizure threshold, including calcium and chloride ion flow through glutamate N-methyl D-aspartate (NMDA) and gamma-aminobutyric acid type A (GABA-A) receptors