Signs and symptoms of overdose with cholinesterase inhibitors such as donepezil can include severe nausea and vomiting, bradycardia, hypotension, perspiration, seizures, muscle weakness Background: Since the introduction of the first cholinesterase inhibitor (ChEI) in 1997, most clinicians and probably most patients would consider the cholinergic drugs, donepezil, galantamine and rivastigmine, to be the first line pharmacotherapy for mild to moderate Alzheimer's disease
The use of cholinesterase inhibitors is only one possible pharmaceutical approach to treating the symptoms of Alzheimer’s disease
Donepezil
Acetylcholine is important in transmitting signals through nerves in the brain for learning and memory
Modifications of donepezil or hybrids with pharmacophores of donepezil in recent five years are summarized in this article
Through pairwise comparisons with placebo and a network meta-analysis, we
Cholinesterase inhibitors (ChEIs), donepezil, galantamine and rivastigmine, delay the breakdown of acetylcholine released into synaptic clefts and so enhance cholinergic neurotransmission
Pisa syndrome due to a cholinesterase inhibitor (Donepezil): A case report
A recent meta-analysis showed that cholinesterase inhibitors (ChEIs) (donepezil, galantamine, and rivastigmine) were superior to placebo in improving cognitive function in patients with AD ( Tan et al
These drugs have been approved for use in mild to moderate Alzheimer’s disease
In Alzheimer’s there is also a loss of the nerve cells that use acetylcholine
Rivastigmine is a 'pseudo‐irreversible' inhibitor of acetylcholinesterase and also of
Methods: The Okayama Memantine Study was used to compare the clinical effects of combination therapy of donepezil plus memantine (n = 61) or
1) Cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block ( 5