Manufacturer advises caution (risk of increased plasma concentration, no information available in severe impairment)
In addition, serotonin is also affected by the blocking of central alpha 2 -receptors
It appears to exert its therapeutic effect via an overall increase in serotonin, norepinephrine, and dopamine levels, although not via the traditional blockade of
Drug Images Highlights for mirtazapine Mirtazapine oral tablets are available as brand-name drugs and generic drugs
It is an antagonist of presynaptic α2
SNRIs are
Effect of mirtazapine versus selective serotonin reuptake inhibitors on benzodiazepine use in patients with major depressive disorder: a pragmatic, multicenter
It is a centrally-acting alpha 2 antagonist as well as a blocker of
Medical experts believe mirtazapine works by balancing chemicals in the brain (such as serotonin and noradrenaline) that are thought to affect mood and emotions
Comments: May increase the dose every 1 to 2 weeks to a maximum 45 mg/day according to patient response
Along with its needed effects, mirtazapine may cause some unwanted effects
Side effects
If you have problems with your liver or kidneys your doctor might prescribe a lower dose
unusual tiredness or weakness
• Serotonin Syndrome: Increased risk when co-administered with other serotonergic drugs (e
This is not a complete list of side effects and others may occur
Use Caution/Monitor
In healthy male subjects (n=18), phenytoin (200 mg daily, at steady state) increased mirtazapine (30 mg daily, at steady state) clearance about 2-fold, resulting in a decrease in average plasma mood, anxiety, psychotic or thought disorders, including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake The novel antidepressant mirtazapine has been shown to increase extracellular noradrenaline and dopamine in the medial prefrontal cortex
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2 Mirtazapine shows rapid improvement in the symptoms of depression, with minimal anticholinergic or serotonin-related adverse effects
3
However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist
Stroke, history of—May cause side effects to become worse
Remeron enhances the activity around the receptors for serotonin and norepinephrine, so unlike the SSRIs and SNRIs, Remeron stimulates your brain to release more of the serotonin and norepinephrine it has
However, the increase may have been due to the depression itself or other factors rather than the mirtazapine
Norepinephrine