See more Ciprofloxacin is a fluoroquinolone antibiotic that can be taken orally or by injection
Ciprofloxacin is eliminated primarily by renal excretion; however, the
250-750mg BID
500 mg q12h (avoid 875 mg tabs) 500 mg q24h (avoid 875 mg tabs) 500 mg q12h (avoid 875
In patients with severe infections and severe renal impairment, a unit dose of 750 mg may be administered at the intervals noted above
The spectrum of activity, mechanisms of action and resistance, important resistance patterns, and adverse effects of commonly available fluoroquinolones (ie
Continuous Renal Replacement Therapy Dosing Guidance Updated February 2023 Back to Top Medication Indications & Comments Anephric Dose 1 L/Hr CRRT 2 L/Hr CRRT 3
, up to 2,400 mg daily) are estimated to be required for patients with augmented renal clearance (estimated glomerular filtration
Dosing: Antimicrobial Dosing in Intermittent & Continuous Hemodialysis
5 mg ciprofloxacin
Thus, active tubular secretion would seem to play a significant role in its elimination
Accurately assessing renal function and determining the influence of renal replacement therapy on antibiotic
DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 20 to 50 : Dose as in normal renal function ; 10 to 20 : 50–100% of normal dose; 10 : 50% of normal dose
2
It is effective against most gram-positive and gram-negative organisms
Some patient factors also influence the decision to adjust drug doses, such as the degree of renal disease and patient size
– Monitor renal function before treatment and at least once weekly
The use of Ciprofloxacin 1000 mg XR tablets is not recommended in this patient population
Standard dosing 0
The urinary excretion of ciprofloxacin is virtually complete within 24 hours after dosing